Actg 076 is a phase iii, randomized, doubleblind, placebocontrolled clinical trial, designed to evaluate whether zidovudine azt administered. Timeline 1994 the ryan white hivaids program a living history. Injectable preexposure prophylaxis for hiv prevention. Daids pab branch chief worked in daids pab from 2009 20, then september 2016 present fun facts. Protocol this trial protocol has been provided by the authors to give readers additional information about their work. This study was a multicenter randomized, doubleblind, placebocontrolled trial. Zidovudine for the prevention of hiv transmission from mother to.
Pediatric aids clinical trials group protocol 076 study group to. One of the strategies implemented for diminishing the frecuency of infection in infants is zidovudine treatment of motherchild unit according to the protocol actg 076 that demostrated an important reduction in vertical transmission. The main route of human immunodeficiency virus hiv infection in children is from mother to child. Since the 076 study 16 clinical trials in the mid 1990s were conducted in from accounting 076 at university of california, irvine. Siglas utilizadas actg 076 protocolo 076 do aids clinical trial group arv antirretrovirais azt zidovudina cdc centers for disease control and prevention dou diario oficial da uniao dst. Pdf evaluation of preventive measures for motherto. Zdv to prevent perinatal hiv transmission actg protocol 076. Zidovudine for the prevention of hiv transmission from. Since the 076 study 16 clinical trials in the mid 1990s. In particular, the pediatric aids clinical trials group actg protocol 076 study was launched in the united states and france in 1991 to test the efficacy and safety of zidovudine in preventing mothertoinfant hiv transmission. The preventive measures established for the aids clinical trial group protocol 076 actg 076.
On february 21, 1994, the national institutes of healths national institute of allergy and infectious diseases niaid and national institute of child health and human development nichd announced preliminary results from a randomized, multicenter, doubleblinded clinical trial of zidovudine zdv to prevent hiv transmission from mothers to their infants aids clinical trials group actg protocol 076. Recommendations of the us public health service task. Copies can be purchased from superintendent of documents, u. Risk factors for perinatal human immunodeficiency virus. Actg 076 is a phase iii, randomized, doubleblind, placebocontrolled clinical trial, designed to evaluate whether zidovudine azt administered to hivinfected pregnant women and their infants could reduce the rate of transmission from mother to infant.
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